直肠给予地西泮治疗失神状态：一项药效学研究。
Rectal diazepam in the treatment of absence status: a pharmacodynamic study.
作者信息
Milligan N, Dhillon S, Richens A, Oxley J
出版信息
J Neurol Neurosurg Psychiatry. 1981 Oct;44(10):914-7. doi: 10.1136/jnnp.44.10.914.
Abstract
Rectal administration of diazepam is highly effective in terminating absence status as judged by reduction of spike-wave activity in the EEG. Pharmacokinetic studies indicate that diazepam can have antiepileptic properties at serum levels well below those previously reported as being necessary to achieve a therapeutic effect.
摘要
通过脑电图中棘波活动的减少判断，直肠给予地西泮在终止失神状态方面非常有效。药代动力学研究表明，地西泮在血清水平远低于先前报道的达到治疗效果所需水平时就可具有抗癫痫特性。
相似文献
1
Rectal diazepam in the treatment of absence status: a pharmacodynamic study.直肠给予地西泮治疗失神状态：一项药效学研究。
J Neurol Neurosurg Psychiatry. 1981 Oct;44(10):914-7. doi: 10.1136/jnnp.44.10.914.
2
Rectal diazepam in pediatric status epilepticus.
Am J Emerg Med. 1989 Mar;7(2):168-72. doi: 10.1016/0735-6757(89)90131-9.
3
Effects of the rectal administration of diazepam. Diazepam concentrations in children undergoing general anaesthesia.
Br J Anaesth. 1985 Jun;57(6):578-80. doi: 10.1093/bja/57.6.578.
4
Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: A systematic review with meta-analysis.非静脉注射咪达唑仑与静脉注射或直肠给药地西泮治疗早期癫痫持续状态：一项系统评价与荟萃分析
Epilepsy Behav. 2015 Aug;49:325-36. doi: 10.1016/j.yebeh.2015.02.030. Epub 2015 Mar 25.
5
Plasma-diazepam in infants after rectal administration in solution and by suppository.婴儿直肠给予溶液和栓剂后血浆中地西泮的情况。
Acta Paediatr Scand. 1977 Sep;66(5):563-7. doi: 10.1111/j.1651-2227.1977.tb07947.x.
6
Diazepam in rectal solution as premedication in children, with special reference to serum concentrations.
Br J Anaesth. 1981 Dec;53(12):1269-72. doi: 10.1093/bja/53.12.1269.
7
Treatment of electrical status epilepticus by short diazepam (DZP) cycles after DZP rectal bolus test.
Brain Dev. 1995 Sep-Oct;17(5):330-3. doi: 10.1016/0387-7604(95)00076-n.
8
Medical management with diazepam for electrical status epilepticus during slow wave sleep in children.儿童睡眠期电持续状态癫痫发作的地西泮药物治疗。
Pediatr Neurol. 2014 Mar;50(3):238-42. doi: 10.1016/j.pediatrneurol.2013.11.002. Epub 2013 Nov 12.
9
Changes in the plasma diazepam concentration and its anticonvulsant effect after the discharge of a diazepam suppository from the rectum in rats.大鼠直肠给予地西泮栓剂后血浆地西泮浓度及其抗惊厥作用的变化。
Methods Find Exp Clin Pharmacol. 2007 Jul-Aug;29(6):401-4. doi: 10.1358/mf.2007.29.6.1119163.
10
Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.儿童急性强直阵挛性惊厥（包括惊厥性癫痫持续状态）的药物管理。
Cochrane Database Syst Rev. 2002(4):CD001905. doi: 10.1002/14651858.CD001905.
引用本文的文献
1
The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters.鼻子有门道：包括癫痫丛集在内的神经系统疾病鼻内给药的机遇与挑战。
Epilepsy Behav Rep. 2022 Dec 28;21:100581. doi: 10.1016/j.ebr.2022.100581. eCollection 2023.
2
Outpatient pharmacotherapy and modes of administration for acute repetitive and prolonged seizures.急性重复性和持续性癫痫发作的门诊药物治疗及给药方式。
CNS Drugs. 2015 Jan;29(1):55-70. doi: 10.1007/s40263-014-0219-6.
3
Fosphenytoin: clinical pharmacokinetics and comparative advantages in the acute treatment of seizures.磷苯妥英：癫痫急性治疗中的临床药代动力学及比较优势
Clin Pharmacokinet. 2003;42(1):33-58. doi: 10.2165/00003088-200342010-00002.
4
A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients.一项关于单次直肠及口服地西泮预防成年癫痫患者连续性癫痫发作的临床试验。
J Neurol Neurosurg Psychiatry. 1984 Mar;47(3):235-40. doi: 10.1136/jnnp.47.3.235.
5
Pharmacokinetics of rectal drug administration, Part II. Clinical applications of peripherally acting drugs, and conclusions.直肠给药的药代动力学，第二部分。外周作用药物的临床应用及结论。
Clin Pharmacokinet. 1991 Aug;21(2):110-28. doi: 10.2165/00003088-199121020-00003.
本文引用的文献
1
Blood levels of diazepam (Valium) and N-desmethyl diazepam in the epileptic child. A preliminary report.
Psychiatr Neurol Neurochir. 1971 Mar-Apr;74(2):153-8.
2
Effects of different rates of absorption of two benzodiazepins on subjective and objective parameters. Significance for clinical use and risk of abuse.
Eur J Clin Pharmacol. 1974;7(3):201-11. doi: 10.1007/BF00560382.
3
Serum concentrations of diazepam in subjects with epilepsy.
Arch Neurol. 1973 Sep;29(3):191-4. doi: 10.1001/archneur.1973.00490270073012.
4
Benzodiazepines in the treatment of epilepsy. A review.
Epilepsia. 1973 Sep;14(3):277-310. doi: 10.1111/j.1528-1157.1973.tb03965.x.
5
Plasma concentrations of diazepam and its metabolites after peroral, intramuscular, and rectal administration. Correlation between plasma concentration and sedatory effect of diazepam.
Int J Clin Pharmacol Biopharm. 1975 Dec;12(4):427-32.
6
Plasma levels of diazepam after parenteral and rectal administration in children.
Epilepsia. 1975 Jun;16(2):277-83. doi: 10.1111/j.1528-1157.1975.tb06058.x.
7
Plasma diazepam levels after single dose oral and intramuscular administration.
Anaesthesia. 1975 Mar;30(2):164-9. doi: 10.1111/j.1365-2044.1975.tb00828.x.
8
Plasma-diazepam in infants after rectal administration in solution and by suppository.婴儿直肠给予溶液和栓剂后血浆中地西泮的情况。
Acta Paediatr Scand. 1977 Sep;66(5):563-7. doi: 10.1111/j.1651-2227.1977.tb07947.x.
9
Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children.直肠给予地西泮溶液用于婴幼儿和儿童惊厥的急性治疗。
Arch Dis Child. 1979 Nov;54(11):855-7. doi: 10.1136/adc.54.11.855.
10
Absorption of diazepam in man following rectal and parenteral administration.地西泮经直肠和非肠道给药后在人体中的吸收情况。
Acta Pharmacol Toxicol (Copenh). 1979 Aug;45(2):87-90. doi: 10.1111/j.1600-0773.1979.tb02365.x.
Zotero 插件