肠道钙转运：西咪替丁的作用

Intestinal calcium transport: effect of cimetidine.

作者信息

Ghishan F K, Walker F, Meneely R, Patwardhan R, Speeg K V

出版信息

J Nutr. 1981 Dec;111(12):2157-61. doi: 10.1093/jn/111.12.2157.

DOI:10.1093/jn/111.12.2157

Abstract

Recently cimetidine (Tagamet), a widely used drug for peptic ulcer disease, was found to decrease serum levels of calcium and immunoreactive parathyroid hormone in patients with hyperparathyroidism. Since parathyroid hormone action is closely related to calcium homeostasis, we studied the effect of cimetidine on intestinal calcium transport. An in vivo perfusion technique was used for the study of net transport and lumen to mucosa flux of 45calcium. Our results indicate a significant decrease in net calcium transport and lumen to mucosa flux of 45calcium in the rats injected with cimetidine, compared to control rats. Direct addition of cimetidine to the perfusion solution did not alter transport rates significantly. The mechanism by which cimetidine affects calcium transport may be secondary to its effect on the release of parathyroid hormone from the parathyroid gland or an effect on vitamin D metabolism.

摘要

最近，西咪替丁（泰胃美），一种广泛用于治疗消化性溃疡疾病的药物，被发现可降低甲状旁腺功能亢进患者的血清钙水平和免疫反应性甲状旁腺激素水平。由于甲状旁腺激素的作用与钙稳态密切相关，我们研究了西咪替丁对肠道钙转运的影响。采用体内灌注技术研究了45钙的净转运以及从肠腔到黏膜的通量。我们的结果表明，与对照大鼠相比，注射西咪替丁的大鼠的净钙转运以及45钙从肠腔到黏膜的通量显著降低。将西咪替丁直接添加到灌注液中并没有显著改变转运速率。西咪替丁影响钙转运的机制可能继发于其对甲状旁腺释放甲状旁腺激素的影响或对维生素D代谢的影响。