Immelman A, Dreyer G
J S Afr Vet Assoc. 1981 Sep;52(3):191-3.
Plasma levels of oxytetracycline in dogs were compared in a cross-over study. A long-acting formulation and a polyvinylpyrrolidone formulation were injected intramuscularly. Symptoms of histamine release were recorded after the use of polyvinylpyrrolidone formulation. Higher peak plasma concentrations but shorter maintenance of therapeutic concentrations were recorded in the case of the polyvinylpyrrolidone formulation than with the long-acting formulation.
在一项交叉研究中比较了犬血浆中土霉素的水平。将长效制剂和聚乙烯吡咯烷酮制剂进行肌肉注射。使用聚乙烯吡咯烷酮制剂后记录组胺释放症状。与长效制剂相比，聚乙烯吡咯烷酮制剂的血浆峰浓度更高，但治疗浓度的维持时间更短。
