Tarumoto Y, Abe S, Kimura M, Tsuchida T, Noda K, Nakane S, Sasajima M, Ohzeki M
J Toxicol Sci. 1981 Jul;6 Suppl:47-66. doi: 10.2131/jts.6.supplement_47.
Subacute toxicity of hydrocortisone 17-butyrate 21-propionate (HBP) was studied in rats. HBP was percutaneously given to rats with 0.1% and 0.5% creame (0.1% HBP-C, 0.5% HBP-C) and ointment (0.1% HBP-O, 0.5% HBP-O) at the daily dose level of 150 mg per 100 g body weight for 1 month. Rats receiving HBP-C and HBP-O showed some dose-dependent symptoms such as the suppression of body weight gain, emaciation, decrease in the number of white blood cells, hemoglobin, hematocrit, and serum total cholesterol level, regressive changes in adrenals, skin, lymphatic and hematopoietic tissues, which are known as toxic effects of synthetic corticosteroids. These symptoms were comparatively high toxic in male rats and in cream groups, and almost disappeared in rats elapsed recovery time of 1 month after withdrawal of HBP.
研究了17 - 丁酸氢化可的松21 - 丙酸酯（HBP）对大鼠的亚急性毒性。以每日150毫克/100克体重的剂量，将HBP以0.1%和0.5%的乳膏（0.1% HBP - C、0.5% HBP - C）和软膏（0.1% HBP - O、0.5% HBP - O）经皮给予大鼠，持续1个月。接受HBP - C和HBP - O的大鼠出现了一些剂量依赖性症状，如体重增加受抑制、消瘦、白细胞数量减少、血红蛋白、血细胞比容和血清总胆固醇水平降低，肾上腺、皮肤、淋巴和造血组织出现退行性变化，这些都是合成皮质类固醇的已知毒性作用。这些症状在雄性大鼠和乳膏组中毒性相对较高，在停用HBP 1个月的恢复时间后，大鼠的这些症状几乎消失。
