Angelin B, Einarsson K, Hellström K, Leijd B
J Lipid Res. 1978 Nov;19(8):1004-16.
Bile acid and plasma endogenous triglyceride kinetics were determined under standardized dietary conditions in 47 hyperlipidemic subjects with the aid of [14C]cholic acid, [14C]chenodeoxycholic acid, and [3H]glycerol, respectively. On the basis of their lipoprotein pattern the patients were separated into three groups characterized by hyperlipoproteinemia (HLP) type IIa (n = 19), type IIb (n = 6), and type IV (n = 22). In keeping with previous reports from this laboratory the total bile acid formation reports from this laboratory the total bile acid formation in HLP type IV (19.5 +/- 2.2) mumol kg-1d-1, mean +/- SEM) exceeded that encountered in type IIa (10.7 +/- 0.9 mumol kg-1d-1, P less than 0.005). This difference was mainly due to an increased synthesis of cholic acid in type IV HLP (12.7 +/- 1.7 mumol kg-1d-1 vs. 6.1 +/- 0.5 mumol kg-1d-1, P less than 0.005). Bile acid formation in type IIb HLP was essentially within the limits recorded for type IIa. Apparent plasma triglyceride formation (as calculated from the 10-hr radioactivity decay curve) averaged 10.5 +/- 0.7 mumol kg-1hr-1 in type IIa HLP and was significantly higher in type IIb (20.7 +/- 1.9 mumol kg-1hr-1, P less than 0.001) and in type IV (22.1 +/- 1.4 mumol kg-1hr-1, P less than 0.001). The apparent fractional turnover rate of plasma triglyceride in type IV HLP (0.147 +/- 0.011 hr-1) was lower than that encountered in type IIa (0.188 +/- 0.008, P less than 0.01) and in type IIb (0.177 +/- 0.011 hr-1). The apparent production of plasma triglycerides and the formation of cholic acid correlated in type IIa (r = +0.69, P less than 0.001) and in type IV HLP (r = +0.70, P less than 0.001). A similar pattern was seen for total bile acid formation, while chenodeoxycholic acid showed a correlation to apparent triglyceride synthesis only in type IV HLP. It is suggested that an increased formation of plasma triglycerides--monitoring very low density lipoprotein synthesis--is linked to an enhanced degradation of cholesterol to bile acids and that there is an integrated regulation of the metabolism of these two parameters.
在标准化饮食条件下，分别借助[14C]胆酸、[14C]鹅去氧胆酸和[3H]甘油，测定了47名高脂血症患者的胆汁酸和血浆内源性甘油三酯动力学。根据脂蛋白模式，将患者分为三组，分别以IIa型（n = 19）、IIb型（n = 6）和IV型（n = 22）高脂蛋白血症（HLP）为特征。与本实验室先前的报告一致，IV型HLP中总胆汁酸生成量（19.5±2.2）μmol·kg-1·d-1（均值±标准误）超过IIa型（10.7±0.9）μmol·kg-1·d-1（P<0.005）。这种差异主要是由于IV型HLP中胆酸合成增加（12.7±1.7）μmol·kg-1·d-1 对比 （6.1±0.5）μmol·kg-1·d-1，P<0.005）。IIb型HLP中的胆汁酸生成基本在IIa型记录的范围内。IIa型HLP中表观血浆甘油三酯生成量（根据10小时放射性衰减曲线计算）平均为10.5±0.7μmol·kg-1·hr-1，IIb型（20.7±1.9）μmol·kg-1·hr-1（P<0.001）和IV型（22.1±1.4）μmol·kg-1·hr-1（P<0.001）显著更高。IV型HLP中血浆甘油三酯的表观分数周转率（0.147±0.011）hr-1低于IIa型（0.188±0.008，P<0.01）和IIb型（0.177±0.011）hr-1。IIa型（r = +0.69，P<0.001）和IV型HLP（r = +0.70，P<0.001）中血浆甘油三酯的表观生成量与胆酸生成相关。总胆汁酸生成也呈现类似模式，而鹅去氧胆酸仅在IV型HLP中与表观甘油三酯合成相关。提示血浆甘油三酯生成增加（监测极低密度脂蛋白合成）与胆固醇向胆汁酸的降解增强有关，并且这两个参数的代谢存在综合调节。
