Jakubowska T, Koziak M, Lipczyńska-Lojkowska W, Niedzielska K, Witkowska-Olearska K, Zieliński J J
Neurol Neurochir Pol. 1981 May-Jun;15(3):303-8.
The authors studied 168 children of mothers with the diagnosis of epilepsy, with 94 of them aged below 15 years whose conception occurred already during the disease of the mother. The control group included 94 children of healthy mothers. These groups of children were matched for sex and age. The general condition was analysed with particular reference to congenital anomalies, neurological condition and psychological investigation. A statistically significantly higher frequency of seizures was observed in the children of epileptic mothers as compared with controls. Occurrence of epileptic seizures and treatment with anticonvulsants in pregnancy create an additional risk of congenital anomalies developing in offsprings, it is possible that they predispose also to premature labours. No significant effect on the psychic state of the children was found.
作者研究了168名母亲被诊断患有癫痫的儿童,其中94名年龄在15岁以下,他们是在母亲患病期间受孕的。对照组包括94名健康母亲的孩子。这些儿童组在性别和年龄上相匹配。对一般情况进行了分析,特别涉及先天性异常、神经状况和心理调查。与对照组相比,癫痫母亲的孩子中癫痫发作的频率在统计学上显著更高。孕期癫痫发作和使用抗惊厥药治疗会增加后代发生先天性异常的额外风险,也有可能导致早产。未发现对儿童心理状态有显著影响。