Aozasa K, Ikeda H, Masaki N, Watanabe Y
Pathol Res Pract. 1981 Jul;172(1-2):161-9. doi: 10.1016/S0344-0338(81)80131-8.
The clinical records and histologic materials from 7 cases with malignant lymphoma (ML) in the nose were examined, and the results were compared to those in malignant histiocytosis (MH) presenting as lethal midline granuloma previously reported by us. The main differences in the clinical findings were 1) younger initiation of the disease in MH than in ML (mean values were 56 and 37 years of age, respectively); 2) ML showed a polypoid nasal mass with necrosis but MH showed necrotic granulomatous lesions; and 3) much better survival in ML than in MH. The histological findings of malignant lymphoma differed from malignant histiocytosis not only in monotony but also in cytologic details. Alpha-naphthyl acetate and butyrate esterase reactions gave clear distinction between the two diseases. From these findings, we conclude that malignant lymphoma should be clinicopathologically separated from malignant histiocytosis.
对7例鼻腔恶性淋巴瘤（ML）的临床记录和组织学材料进行了检查，并将结果与我们之前报道的表现为致死性中线肉芽肿的恶性组织细胞增多症（MH）的结果进行了比较。临床发现的主要差异为：1）MH发病年龄比ML小（平均年龄分别为56岁和37岁）；2）ML表现为伴有坏死的息肉样鼻腔肿物，而MH表现为坏死性肉芽肿性病变；3）ML的生存率比MH高得多。恶性淋巴瘤的组织学发现与恶性组织细胞增多症的不同之处不仅在于细胞单一性，还在于细胞细节。α-萘乙酸酯酶和丁酸酯酶反应可明确区分这两种疾病。根据这些发现，我们得出结论，恶性淋巴瘤在临床病理上应与恶性组织细胞增多症相区分。
