Winter J C
Pharmacol Biochem Behav. 1981 Aug;15(2):157-9. doi: 10.1016/0091-3057(81)90170-2.
Six rats were trained to discriminate the effects of caffeine (60 mg/kg, pretreatment time: 1 hour) and saline in a two-lever choice task using a fixed ratio 10 schedule of water reinforcement. Stimulus control was assumed to be present when 80% or more of the first ten responses were appropriate for the treatment condition on each of five consecutive days. The mean number of sessions prior to the onset of criterion performance was 22 (SE = 3; range = 11--32). In trained subjects, doses of caffeine of 30, 10, and 3 mg/kg were followed by a progressively smaller proportion of responses on the caffeine-appropriate lever. Stimulus control by caffeine began to diminish about four hours after administration and was completely absent after 24 hours. The caffeine cue generalized partially to d-amphetamine and completely to aminophylline. Neither pizotyline nor spiperone antagonized stimulus control induced by caffeine.
六只大鼠被训练在一个双杠杆选择任务中辨别咖啡因（60毫克/千克，预处理时间：1小时）和生理盐水的作用，该任务采用固定比例10的水强化程序。当在连续五天中的每一天，前十次反应中有80%或更多与治疗条件相符时，假定存在刺激控制。达到标准表现之前的平均训练次数为22次（标准误 = 3；范围 = 11 - 32）。在经过训练的受试者中，30毫克/千克、10毫克/千克和3毫克/千克的咖啡因剂量之后，在与咖啡因对应的杠杆上做出反应的比例逐渐减小。咖啡因给药约四小时后刺激控制开始减弱，24小时后完全消失。咖啡因线索部分泛化到右旋苯丙胺，完全泛化到氨茶碱。哌唑嗪和螺哌隆均未拮抗咖啡因诱导的刺激控制。
