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仅用抗生素治疗治愈广泛脑诺卡菌病。病例报告。

Extensive cerebral nocardiosis cured with antibiotic therapy alone. Case report.

作者信息

Kirmani N, Tuazon C U, Ocuin J A, Thompson A M, Kramer N C, Geelhoed G W

出版信息

J Neurosurg. 1978 Dec;49(6):924-8. doi: 10.3171/jns.1978.49.6.0924.

DOI:10.3171/jns.1978.49.6.0924
PMID:731312
Abstract

A 34-year-old renal transplant recipient developed multiple soft tissue and extensive cerebral nocardiosis. The number and locations of the cerebral abscesses and probable areas of cerebritis precluded surgical drainage procedures. Gradual resolution of all the cerebral lesions occurred over a period of 6 months with antibiotic therapy alone. A review of the literature revealed only one previous case of a patient with pulmonary nocardiosis who had a probable secondary brain abscess and who survived without surgical drainage. Thus, if surgical drainage is not possible, antibiotic therapy alone may offer a hope of survival in what otherwise has been considered a uniformly fatal disease.

摘要

一名34岁的肾移植受者发生了多处软组织和广泛的脑诺卡菌病。脑脓肿的数量和位置以及可能的脑炎性区域使手术引流无法进行。仅通过抗生素治疗,所有脑损伤在6个月内逐渐消退。文献回顾显示,之前仅有一例肺诺卡菌病患者可能继发脑脓肿,且未经手术引流而存活。因此,如果无法进行手术引流,仅抗生素治疗可能为这种原本被认为必死无疑的疾病带来生存希望。

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Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy.基于当前分子分类学的诺卡氏菌属的临床和实验室特征。
Clin Microbiol Rev. 2006 Apr;19(2):259-82. doi: 10.1128/CMR.19.2.259-282.2006.
3
Brain abscess in solid organ transplant recipients receiving cyclosporine-based immunosuppression.
接受基于环孢素免疫抑制治疗的实体器官移植受者发生脑脓肿。
Arch Surg. 1997 Mar;132(3):304-10. doi: 10.1001/archsurg.1997.01430270090019.
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Nocardia species: host-parasite relationships.诺卡氏菌属:宿主与寄生虫的关系。
Clin Microbiol Rev. 1994 Apr;7(2):213-64. doi: 10.1128/CMR.7.2.213.
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Successful treatment of nocardial thigh abscess and possible brain abscess with co-trimoxazole.
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Acta Neurochir (Wien). 1987;85(3-4):138-47. doi: 10.1007/BF01456110.
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Nocardial cerebral abscess cured with imipenem/amikacin and enucleation.用亚胺培南/阿米卡星及摘除术治愈的诺卡菌性脑脓肿
Neurosurg Rev. 1989;12(4):333-40. doi: 10.1007/BF01780852.