实验性骨折愈合：使用放射性核素骨显像进行评估：简要通讯

Experimental fracture healing: evaluation using radionuclide bone imaging: concise communication.

作者信息

Gumerman L W, Fogel S R, Goodman M A, Hanley E N, Kappakas G S, Rutkowski R, Levine G

出版信息

J Nucl Med. 1978 Dec;19(12):1320-3.

Abstract

Radionuclide bone imaging was performed in a rabbit model to observe the course of fracture healing and to establish criteria for distinguishing nonunion and delayed healing from normal healing. Sequential gamma-camera images (with pinhole collimator) were collected and subjected to computer analysis. Five groups were established: a) control--immobilization; b) control--immobilization plus periosteal stripping; c) simple fracture--osteotomy; d) delayed union--osteotomy plus periosteal stripping; and e) nonunion--osteotomy, periosteal stripping and polymethyl methacrylate interposed between fracture fragments. Histographic representation of absolute count rates along rabbit tibias followed a predictable pattern in the simple-fracture and delayed-union groups. They differed only in the time of appearance of phases. The nonunion group demonstrated no recognizable sequential pattern. In this experimental model, serial bone scanning with quantitative data analysis has shown potential for indicating the course of healing in fractures and for serving as a guide to treatment.

摘要

在兔模型中进行放射性核素骨显像，以观察骨折愈合过程，并建立区分骨不连、延迟愈合与正常愈合的标准。采集连续的γ相机图像（使用针孔准直器）并进行计算机分析。设立了五组：a）对照组——制动；b）对照组——制动加骨膜剥离；c）单纯骨折组——截骨术；d）延迟愈合组——截骨术加骨膜剥离；e）骨不连组——截骨术、骨膜剥离并在骨折断端间置入聚甲基丙烯酸甲酯。沿兔胫骨的绝对计数率的组织学表现，在单纯骨折组和延迟愈合组中遵循可预测的模式。它们仅在各阶段出现的时间上有所不同。骨不连组未显示出可识别的连续模式。在该实验模型中，采用定量数据分析的系列骨扫描已显示出指示骨折愈合过程及作为治疗指南的潜力。