López-Merino V, Insa L D, Ferrero J A, Botella S, Llopis R, Merino J, Morell S, Chorro J
Rev Esp Fisiol. 1981 Jun;37(2):221-30.
Twenty four patients were subjected to an electrophysiologic clinical procedure. The conventional extrastimulus test was applied to verify the relation between conduction time increase through the atrioventricular node of the extrastimulus beat (delta AH), and its preceding interval (A1A2). Following the least square root method the parameters of the hyperbolic model delta AH.A1A2 = m . delta AH + n were adjusted. The correlation coefficients obtained and tested in all cases were very high and significant. From this hyperbolic equation it was possible to determine the equations for the effective refractory period (ERPe = m) and functional refractory period (FRPe = ERPe + n). The theoretical values for refractoriness approached very closely those of the actually measured ERP and FRP, in all cases. This model proved to be, in respect to adjustments and especially in calculating refractory periods, at least as good as the exponential model proposed previously by other authors.
24名患者接受了一项电生理临床程序。应用传统的额外刺激试验来验证额外刺激搏动通过房室结的传导时间增加（δAH）与其前间期（A1A2）之间的关系。采用最小二乘法对双曲线模型δAH·A1A2 = m·δAH + n的参数进行调整。在所有病例中获得并检验的相关系数都非常高且具有显著性。从这个双曲线方程可以确定有效不应期（ERPe = m）和功能不应期（FRPe = ERPe + n）的方程。在所有病例中，不应期的理论值与实际测量的ERP和FRP非常接近。就调整而言，尤其是在计算不应期方面，该模型至少与其他作者先前提出的指数模型一样好。
