The interaction of histone H1 with pyran co-polymer.

Complexes formed by the interaction of histone H1 and the immunomodulator Pyran co-polymer, were evaluated using nephelometric titration. At a constant concentration of histone (10 microgram/ml), maximum turbidity was obtained at a Pyran concentration of 2 microgram/ml. Titration of H1 by Pyran was found to be sensitive to ionic strength. Concentration of Na+ greater than 200 mM or Mg+2 greater than 3 mM apparently blocked Pyran . H1 complex formation.