Rabkin S W, Bose D
Res Commun Chem Pathol Pharmacol. 1981 Oct;34(1):55-67.
To study the electrophysiologic effects of adriamycin, transmembrane action potential characteristics of canine purkinje fibers were analyzed. Adriamycin significantly (p less than 0.05) prolonged action potential duration and refractory period but did not significantly alter resting membrane potential, action potential amplitude, dV/dt max and threshold for stimulation. Furthermore adriamycin effects were not reversible 20 minutes after the drug had been 'washed out'. These data indicate that adriamycin has significant cardiac electrophysiology effects that may account for its toxicity in man and that these effects are not quickly reversible.
为研究阿霉素的电生理效应，分析了犬浦肯野纤维的跨膜动作电位特征。阿霉素显著（p小于0.05）延长动作电位时程和不应期，但对静息膜电位、动作电位幅度、最大去极化速率（dV/dt max）和刺激阈值无显著影响。此外，在药物“洗脱”20分钟后，阿霉素的作用仍不可逆。这些数据表明，阿霉素具有显著的心脏电生理效应，这可能是其对人类产生毒性的原因，且这些效应不会很快逆转。
