Hall C A, Kelly J D, Whitlock H V, Ritchie L
Res Vet Sci. 1981 Jul;31(1):104-6.
Two long-acting anthelmintics, closantel and disophenol, were tested by treatment 90, 60 and 30 days before challenge with a thiabendazole selected laboratory strain of Haemonchus contortus. The sheep were slaughtered 28 days after infection for total worm counts. A significant reduction in the number of adults remaining at autopsy was recorded after treatment with both anthelmintics 30 and 60 days before challenge but there was zero efficacy when the animals were treated 90 days before challenge. No significant difference was exhibited between the two compounds. Variability in response was recorded between animals on the 60 day period of treatment, which for disophenol may be dose related because animals receiving the lower volumes showed higher worm counts. For both anthelmintics a variability in the rate of metabolism may be responsible. The possibility offered by both anthelmintics for treating benzimidazole resistant strains of H contortus is discussed.
选用两种长效驱虫药氯氰碘柳胺和敌百虫酚，在对绵羊用噻苯达唑选育的实验室捻转血矛线虫株进行攻虫感染前90天、60天和30天进行给药处理。感染28天后将绵羊宰杀以进行全虫计数。在攻虫感染前30天和60天用这两种驱虫药处理后，尸检时记录到残留成虫数量显著减少，但在攻虫感染前90天对动物进行处理时驱虫效果为零。两种化合物之间未表现出显著差异。在60天的治疗期内，动物之间的反应存在差异，对于敌百虫酚而言，这种差异可能与剂量有关，因为接受较低剂量的动物体内虫数较多。对于这两种驱虫药来说，代谢速率的差异可能是原因所在。文中讨论了这两种驱虫药用于治疗对苯并咪唑耐药的捻转血矛线虫株的可能性。
