Maingi N, Thamsborg S M, Gichohi V M, Munyua W K, Gathuma J M
Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nairobi, Kenya.
Vet Res Commun. 1997 Nov;21(8):547-57. doi: 10.1023/a:1005966730387.
The strategic use of closantel, a narrow-spectrum salicylanilide anthelmintic against bloodsucking helminths, and of albendazole, a broad-spectrum benzimidazole anthelmintic, in the control of gastrointestinal nematodes of sheep was investigated on a farm in Nyandarua District in the highlands of Kenya. Thirty Corriedale female lambs aged between 9 and 12 months were assigned to three treatment groups of 10 lambs each. The three groups were set stocked on separate paddocks for 12 months. Lambs in group 1 (strategic treatment group) were treated with closantel and albendazole at the beginning and towards the end of the long rains (April and June, respectively) and towards the end of the short rains. (December). During the intervening dry season, the lambs were treated with albendazole. Lambs in group 2 (suppressive treatment group) were kept 'worm free' by regular deworming with albendazole at 3-weekly intervals for 12 months. The third group of lambs remained untreated (control group). Gastrointestinal nematode infections and pasture infectivity were well controlled in the case of the strategic treatment group. This resulted in higher weight gains, wool production, packed cell volume, and serum albumin and protein concentrations compared with the untreated control lambs. These parameters were comparable between the strategic treatment and the suppressive treatment groups of lambs. It was concluded that worm control strategies based on the epidemiology of the parasites and the sustained anthelmintic action of closantel in combination with broad-spectrum anthelmintics can provide effective control of gastrointestinal nematodes of sheep in the study area.
在肯尼亚高地延达鲁阿区的一个农场，对窄谱水杨酰苯胺驱虫药氯氰碘柳胺（closantel）和广谱苯并咪唑驱虫药阿苯达唑（albendazole）在控制绵羊胃肠道线虫方面的策略性应用进行了研究。30只9至12个月大的考力代母羊被分为三个处理组，每组10只。这三组羊被分别圈养在不同的围场中12个月。第1组（策略性处理组）的羔羊在长雨季开始时（4月）和结束时（6月）以及短雨季结束时（12月）用氯氰碘柳胺和阿苯达唑进行治疗。在中间的旱季，羔羊用阿苯达唑进行治疗。第2组（抑制性处理组）的羔羊通过每隔3周用阿苯达唑定期驱虫12个月来保持“无虫”状态。第三组羔羊不进行治疗（对照组）。对于策略性处理组，胃肠道线虫感染和牧场感染性得到了很好的控制。与未处理的对照羔羊相比，这导致了更高的体重增加、羊毛产量、红细胞压积以及血清白蛋白和蛋白质浓度。这些参数在策略性处理组和抑制性处理组的羔羊之间具有可比性。得出的结论是，基于寄生虫流行病学以及氯氰碘柳胺与广谱驱虫药联合使用的持续驱虫作用的蠕虫控制策略，可以有效控制研究区域内绵羊的胃肠道线虫。
