Costabel U, Matthys H
Respiration. 1981;42(3):141-9. doi: 10.1159/000194420.
The success of 3 different treatment regimens was compared in 15 patients with diffuse fibrosing alveolitis. Improvement or deterioration of lung function (vital capacity (VC) and PaO2 changes during exercise) were used as a control of therapy. The combination of prednisolone and azathioprine proved to be most effective: in 4 of 6 patients both VC and PaO2 improved. Combinations with D-penicillamine resulted in a high number of unwanted side effects: in 5 of 13 treated patients it had to be withdrawn. 6 patients were treated with prednisolone alone; only 1 of them improved. Patients with a short duration of symptoms prior to therapy and initially mild impairment of lung function showed a higher degree of improvement during therapy. The consequence for the management of lung fibrosis is to establish diagnosis and treatment as early as possible.
对15例弥漫性纤维化肺泡炎患者比较了3种不同治疗方案的疗效。肺功能（肺活量（VC）和运动期间的动脉血氧分压（PaO2）变化）的改善或恶化被用作治疗的对照指标。泼尼松龙和硫唑嘌呤联合使用被证明是最有效的：6例患者中有4例的VC和PaO2均有所改善。与青霉胺联合使用产生了大量不良副作用：13例接受治疗的患者中有5例不得不停药。6例患者仅接受泼尼松龙治疗；其中只有1例有所改善。治疗前症状持续时间短且最初肺功能轻度受损的患者在治疗期间改善程度更高。肺纤维化治疗的结果是尽早确立诊断并进行治疗。
