Eriksson G, Swahn C G
Scand J Clin Lab Invest. 1981 Apr;41(2):185-7. doi: 10.3109/00365518109092032.
A lactating woman with spastic paraplegia was given 94 mumol (20 mg) of baclofen orally to study the transport of the drug into breast milk. The concentration of baclofen in serum and milk was determined with a gas chromatographic--mass spectrometric method. The elimination curves in serum and milk showed a similar course, the elimination from milk being delayed about 3 h relative to serum. The total amount of baclofen excreted in the milk during 24 h was about one thousandth of the ingested dose.
为研究巴氯芬向母乳中的转运情况，给一名患有痉挛性截瘫的哺乳期妇女口服了94微摩尔（20毫克）的巴氯芬。采用气相色谱 - 质谱法测定血清和乳汁中巴氯芬的浓度。血清和乳汁中的消除曲线显示出相似的过程，乳汁中的消除相对于血清延迟约3小时。24小时内乳汁中排泄的巴氯芬总量约为摄入剂量的千分之一。
