对镍和铬敏感性的HLA依赖性
HLA dependence of sensitivity to nickel and chromium.
作者信息
Kapoor-Pillarisetti A, Mowbray J F, Brostoff J, Cronin E A
出版信息
Tissue Antigens. 1981 Mar;17(3):261-4. doi: 10.1111/j.1399-0039.1981.tb00699.x.
Abstract
A group of patients with cutaneous sensitivity was compared with another group with cement dermatitis who showed sensitivity to chromate. HLA typing for A and B locus antigens demonstrated a 29% incidence of B21 in the nickel sensitive group (control population 4.9%) and the antigen was not found in 16 patients with chromium sensitivity. It is suggested that this may represent a hapten specific HLA dependent immune response in man.
摘要
将一组皮肤敏感患者与另一组对铬酸盐敏感的水泥性皮炎患者进行了比较。对A和B位点抗原进行的HLA分型显示，镍敏感组中B21的发生率为29%（对照人群为4.9%），而在16例铬敏感患者中未发现该抗原。有人提出，这可能代表了人类中一种半抗原特异性的HLA依赖性免疫反应。
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