Blaskó K, Györgyi S
Acta Biol Med Ger. 1981;40(4-5):465-9.
The effects of the antibiotic primycin on alkali cation transport of human erythrocytes were investigated. Primycin selectively increases the permeability of erythrocytes to alkali-cations according to the sequence: Cs+ greater than Rb+ approximately K+ greater than Na+. The time course of the cation effluxes depends on the antibiotic concentration and can be altered by negatively charged SDS. Some evidence is given for the mechanism of primycin-membrane interaction.
研究了抗生素原霉素对人红细胞碱金属阳离子转运的影响。原霉素根据以下顺序选择性地增加红细胞对碱金属阳离子的通透性：Cs⁺＞Rb⁺≈K⁺＞Na⁺。阳离子外流的时间进程取决于抗生素浓度，并且可被带负电荷的十二烷基硫酸钠改变。给出了一些关于原霉素与膜相互作用机制的证据。
