Vandevelde M, Braund K G, Luttgen P J, Higgins R J
Acta Neuropathol. 1981;55(2):81-7. doi: 10.1007/BF00699232.
The ultrastructure of myelin deficiency in Chow Chow dogs was studied in the spinal cord of a 15-month-old and a 3-year-old animal. It was found that myelination progresses with age in these dogs but is still deficient at the age of 3 years. The findings included axons with thin or uncompacted myelin sheaths, separated from each other by massive astrocytosis, and bizarre myelin formations. Normal numbers of morphologically normal oligodendrocytes were present in the myelin-deficient areas. The disease in these Chow Chow dogs consists of a strongly retarded myelination which is possibly due to a dysfunction or delay in glial maturation.
对一只15个月大以及一只3岁的松狮犬脊髓中髓鞘缺乏的超微结构进行了研究。发现这些犬类的髓鞘形成随年龄增长，但在3岁时仍有缺陷。研究结果包括轴突的髓鞘薄或疏松，被大量星形细胞增生分隔开，以及出现奇异的髓鞘形成。在髓鞘缺乏区域存在形态正常的少突胶质细胞，数量正常。这些松狮犬的疾病表现为髓鞘形成严重迟缓，这可能是由于神经胶质细胞成熟功能障碍或延迟所致。
