Bray G M, Duncan I D, Griffiths I R
Neuropathol Appl Neurobiol. 1983 Sep-Oct;9(5):369-78. doi: 10.1111/j.1365-2990.1983.tb00122.x.
Large axons identified in freeze-fracture replicas of the spinal cord white matter of 'shaking pups' were encircled by spiral processes at the paranodes that appeared to arise from oligodendrocytes. In the axolemma adjacent to some of these processes there were paranode-like intramembranous specializations and node-like accumulations of E-face particles; in other instances, no special contacts formed between axons and the spiral processes. The outer surfaces of the spiral processes, which often apposed astrocytes, frequently contained gap junctions. Although many of the abnormalities identified in this dysmyelinating mutant by freeze-fracture electron microscopy are probably secondary to a more fundamental defect of myelin formation, the prominence of the spiral processes suggests that the encircling of axons by oligodendrocytes may be an independent state of ensheathment and not a passive effect of myelin formation.
在“摇晃幼犬”脊髓白质的冷冻断裂复制品中鉴定出的大型轴突，在 paranodes 处被似乎起源于少突胶质细胞的螺旋状突起环绕。在与其中一些突起相邻的轴膜中，有 paranode 样的膜内特化结构和 E 面颗粒的节点样聚集；在其他情况下，轴突与螺旋状突起之间没有形成特殊接触。螺旋状突起的外表面经常与星形胶质细胞相邻，且常常含有缝隙连接。尽管通过冷冻断裂电子显微镜在这种脱髓鞘突变体中鉴定出的许多异常可能继发于髓鞘形成的更基本缺陷，但螺旋状突起的突出表明少突胶质细胞对轴突的环绕可能是一种独立的包裹状态，而不是髓鞘形成的被动效应。
