Hellquist H, Olofsson J
Acta Otolaryngol. 1981 Jul-Aug;92(1-2):157-65. doi: 10.3109/00016488109133251.
Photometric examination of vocal cord epithelia disclosed no difference in the nuclear DNA content or nuclear area of normal and keratotic laryngeal epithelia. For 2 out of 3 epithelia displaying hyperplasia the values were slightly elevated. There seem to be no morphologic or photometric grounds for considering either hyperplasia or keratosis to be premalignant. Eight patients with moderate dysplasia were selected; 3 with and 5 without subsequent development of severe dysplasia or carcinoma in situ. In all 8 cases the DNA values were not increased, but in 6 there was an increased variation about the mean. There were no morphologic or photometric differences between the epithelia subsequently developing severe dysplasia or carcinoma in situ and those that did not. The 3 patients developing severe dysplasia or carcinoma in situ were then followed for 112, 27 and 106 months and showed no evidence of invasive carcinoma. The other 5 patients with moderate dysplasia were followed for 48 to 123 months without any sign of recurrent disease. There are no photometric grounds for considering moderate dysplasia as a precancerous lesion. Long-term investigation is required to ascertain the risk that carcinoma in situ or invasive carcinoma will develop in patients with laryngeal hyperplasia, keratosis and moderate dysplasia.
声带上皮的光度测定显示，正常喉上皮和角化性喉上皮的核DNA含量或核面积没有差异。在3个显示增生的上皮中，有2个的值略有升高。似乎没有形态学或光度学依据认为增生或角化是癌前病变。选择了8例中度发育异常的患者；3例随后发展为重度发育异常或原位癌，5例未发展。在所有8例中，DNA值没有增加，但6例的平均值周围变异增加。随后发展为重度发育异常或原位癌的上皮与未发展的上皮之间在形态学或光度学上没有差异。对3例发展为重度发育异常或原位癌的患者进行了112、27和106个月的随访，未发现浸润癌的证据。另外5例中度发育异常的患者随访了48至123个月，没有复发疾病的迹象。没有光度学依据将中度发育异常视为癌前病变。需要进行长期研究以确定喉增生、角化和中度发育异常患者发生原位癌或浸润癌的风险。
