Lolova I, Petrov I
Acta Physiol Pharmacol Bulg. 1981;7(1):60-8.
Electronmicroscopic studies are made of the myenteric ganglia from the lower esophageal, pyloric and ileo-caecal sphincters of cats and rats after intravenous injection of 6-hydroxydopamine. The changes occur as early as the 30th min after treatment and comprise the adrenergic varicosities in all three sphincters studied. The destructive process develops very quickly and on the 4th hour it comprises all adrenergic varicosities. Later during the study there occur degenerative changes along the axons as well. Although each stage in the study is characterized by predomination of a certain change, there is some asynchronousness in the changes. The changes are characteristic of the adrenergic varicosities in the myenteric ganglia of all three sphincters, but there is a difference in the dynamics and extent of the damage.
对静脉注射6-羟基多巴胺后的猫和大鼠的食管下括约肌、幽门括约肌及回盲括约肌的肌间神经节进行了电子显微镜研究。在治疗后30分钟就出现了变化，包括在所研究的所有三个括约肌中的肾上腺素能膨体。破坏过程发展非常迅速，在第4小时时所有肾上腺素能膨体都受到影响。在随后的研究过程中，轴突也出现了退行性变化。尽管研究中的每个阶段都以某种特定变化为主，但这些变化存在一定的异步性。这些变化是所有三个括约肌肌间神经节中肾上腺素能膨体的特征，但在损伤的动态变化和程度上存在差异。
