关于高浓度组胺诱导豚鼠气管舒张的机制
On the mechanism of guinea-pig tracheal relaxation induced by high histamine concentrations.
作者信息
Todorov S
出版信息
Acta Physiol Pharmacol Bulg. 1981;7(2):33-7.
In concentrations higher than 1 X 10(-3)M histamine relaxed guinea-pig tracheal strips previously contracted by lower histamine concentrations. The blocker of H1-histaminergic receptors diphenhydramine (1 X 10(-6)M and 1 X 10(-5)M) and the alpha-adrenoblocker phentolamine (1 X 10(-5)M) potentiated histamine-induced relaxation. The beta-blocker propranolol (1 X 10(-4)M) decreased the histamine relaxant effect. Oxprenolol (1 X 10(-4)M) that is a less potent blocker of the tracheal beta 2-adrenoreceptors and is a partial beta-agonist did not influence histamine-induced relaxation. It is suggested that high histamine concentrations relax the guinea-pig tracheal strips by activating the H2-receptors and by depleting catecholamines in the smooth muscle.
浓度高于1×10⁻³M的组胺可使先前由较低浓度组胺收缩的豚鼠气管条松弛。H1组胺能受体阻滞剂苯海拉明（1×10⁻⁶M和1×10⁻⁵M）和α肾上腺素能阻滞剂酚妥拉明（1×10⁻⁵M）可增强组胺诱导的松弛作用。β受体阻滞剂普萘洛尔（1×10⁻⁴M）可降低组胺的松弛作用。氧烯洛尔（1×10⁻⁴M）是一种对气管β2肾上腺素能受体阻滞作用较弱的药物且是一种部分β激动剂，它不影响组胺诱导的松弛作用。提示高浓度组胺通过激活H2受体和耗尽平滑肌中的儿茶酚胺使豚鼠气管条松弛。
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