Anile C, Zanghi F, Bracali A, Maira G, Rossi G F
Acta Neurochir (Wien). 1981;58(3-4):203-11. doi: 10.1007/BF01407126.
The effects of sodium nitroprusside on intracranial pressure were studied in 10 patients, candidates for surgical treatment, prior to anaesthesia. Blood pressure was lowered to at least 50% of its initial value. In all cases, at the beginning of nitroprusside infusion, both the mean and the pulse intracranial pressures increased (mean increase: 83.2% of the initial value). At a certain moment, however, while the blood pressure continued to fall, the mean intracranial pressure did not increase any more; on the contrary, it decreased. On the other hand, in many cases, the pulse intracranial pressure continued to increase. No neurological or EEG changes were observed. The possible changes of cerebral circulation and CSF dynamics underlying the phenomena observed are discussed.
在10例拟行手术治疗的患者麻醉前，研究了硝普钠对颅内压的影响。血压降至初始值的至少50%。在所有病例中，开始输注硝普钠时，平均颅内压和脉搏颅内压均升高（平均升高：初始值的83.2%）。然而，在某一时刻，尽管血压持续下降，但平均颅内压不再升高；相反，它降低了。另一方面，在许多病例中，脉搏颅内压继续升高。未观察到神经学或脑电图变化。讨论了所观察到的现象背后脑循环和脑脊液动力学的可能变化。
