Beck J F, Bradbury C M, Connors A J, Donini J C
Am Ind Hyg Assoc J. 1981 Nov;42(11):805-9. doi: 10.1080/15298668191420738.
The detoxification of hydrogen sulfide (H2S) by a heme catalyzed oxidation was examined as part of an on-going study of H2S toxicity. Interlocking O2 absorption and sulfide depletion data indicate that both oxyhemoglobin and methemoglobin are effective catalytic agents. Although the latter is more efficacious, the life time of excess sulfide in the presence of oxygen and either of the above is of the order of minutes. It has also been established that the formation of methemoglobin following nitrite administration occurs preferentially under oxygen poor conditions. Under an atmospheric or oxygen enriched environment, which favors sulfide depletion, the nitrite retards sulfide oxidation. Thus nitrite as an antidote for acute H2S intoxication can only be effective within the first few minutes after the exposure, at which time resuscitation and/or ventilation of the victim is likely to produce conditions in which the nitrite actually slows sulfide removal.
作为正在进行的硫化氢毒性研究的一部分，对血红素催化氧化去除硫化氢（H₂S）进行了研究。相互关联的氧气吸收和硫化物消耗数据表明，氧合血红蛋白和高铁血红蛋白都是有效的催化剂。虽然后者更有效，但在有氧气和上述任何一种物质存在的情况下，过量硫化物的寿命约为几分钟。还已确定，亚硝酸盐给药后高铁血红蛋白的形成在缺氧条件下优先发生。在有利于硫化物消耗的大气或富氧环境中，亚硝酸盐会阻碍硫化物氧化。因此，亚硝酸盐作为急性硫化氢中毒的解毒剂，仅在接触后的最初几分钟内有效，此时对受害者进行复苏和/或通气可能会产生亚硝酸盐实际上减缓硫化物清除的情况。
