Myers T J, Ikeda Y, Schwartz S, Pharmakidis A B, Baldini M G
Am J Hematol. 1981 Nov;11(3):299-303. doi: 10.1002/ajh.2830110311.
A patient with primary splenic hairy cell leukemia is reported. This patient presented with massive splenomegaly and pancytopenia due to hypersplenism. Exploratory laparotomy failed to demonstrate any disease outside the spleen and splenic hilar lymph nodes. Splenectomy was the only form of treatment. During the following 21 years, no recurrent hairy cell leukemia has been found. This case allows speculation that hairy cell leukemia may originate in the spleen and that prolonged survival or cure of the disease after splenectomy alone may be due to removal of stem cells in the spleen.
报告了一例原发性脾毛细胞白血病患者。该患者因脾功能亢进出现巨脾和全血细胞减少。剖腹探查未发现脾脏及脾门淋巴结以外的任何病变。脾切除术是唯一的治疗方式。在接下来的21年里，未发现复发性毛细胞白血病。该病例提示，毛细胞白血病可能起源于脾脏，单纯脾切除术后疾病的长期存活或治愈可能是由于清除了脾脏中的干细胞。
