Granulomatous inflammatory reaction to degenerating Desçemet's membrane.

Granulomatous inflammatory reaction to degenerating Desçemet's membrane was found in histopathologic study of a keratoplasty specimen from a case of disciform keratitis following childhood varicella infection. The histologic findings suggest acquired autosensitivity to degenerating Desçemet's membrane as a likely cause for the chronic keratitis. Such a reaction may persist for many years in a corneal leukoma that, clinically, appears free of inflammation.