Kimbrough R L, Mewis L, Stewart R H
Ann Ophthalmol. 1981 Oct;13(10):1171-2.
D-penicillamine is a potent drug used to treat rheumatoid arthritis, Wilson's disease and cystinuria. D-penicillamine has recently been found to cause myasthenia gravis in certain susceptible patients. We present a typical case of one patient who developed myasthenia while taking D-penicillamine. The withdrawal of D-penicillamine and the institution of short-term anticholinesterase therapy resulted in the resolution of this disease. The literature is reviewed and attention is focused on the point that all patients who developed myasthenia while undergoing D-penicillamine therapy had ocular symptoms.
D-青霉胺是一种用于治疗类风湿性关节炎、威尔逊氏病和胱氨酸尿症的强效药物。最近发现，D-青霉胺会使某些易感患者患上重症肌无力。我们介绍一位在服用D-青霉胺期间患上重症肌无力的典型病例。停用D-青霉胺并进行短期抗胆碱酯酶治疗后，该病得到缓解。本文对相关文献进行了综述，并重点关注了所有在接受D-青霉胺治疗期间患上重症肌无力的患者均有眼部症状这一点。
