Zanno C, Zagami L, Terzi I
Ann Osp Maria Vittoria Torino. 1980 Jul-Dec;23(7-12):428-34.
A group of 11 hirsute women with elevated total plasma testosterone (no ovaric neoplasia detectable) was studied by dexamethasone suppression test. Suppression to within normal limits was in 5 patients by dexamethasone alone. After a 5 month continuous therapy ovulation was restored and hirsutism reduced. Suppression was obtained in the other 6 patients only with estroprogestins. These results suggest an interesting hypothesis: hypertestosteronemias related to anovulation might be divided in two classes, the first one in which testosterone is synthetized from adrenal prehormones, the second one in which testosterone is synthetized from acetate.
对一组11名总血浆睾酮水平升高（未检测到卵巢肿瘤）的多毛症女性进行了地塞米松抑制试验研究。仅用地塞米松，5名患者的睾酮水平被抑制到正常范围内。经过5个月的持续治疗，排卵恢复，多毛症减轻。另外6名患者仅使用雌激素孕激素才获得抑制效果。这些结果提示了一个有趣的假说：与无排卵相关的高雄激素血症可能分为两类，第一类中睾酮由肾上腺前体激素合成，第二类中睾酮由醋酸盐合成。
