Rotmensch H H, Leiser A, Dan M, Klejman A, Livni E, Ilie B, Messer G, Kadish U, Liron M
Arch Intern Med. 1981 Dec;141(13):1797-1801. doi: 10.1001/archinte.141.13.1797.
Cholestatic jaundice developed in four patients after the administration of prajmalium bitartrate. The clinical, histologic, ultrastructural, and immunologic findings were determined. In all patients, the clinical and morphologic features indicated idiosyncrasy. Two antibodies distributed in a granular pattern along the bile canaliculi were detected by immunofluorescence in all patients. In one patient, autoimmune markers were found in the serum, and in two instances, the migration-inhibition factor assay against the offending drug was found to be positive. The data support the concept that immunologic processes may participate in the production of the cholestatic syndrome.
