一例利福平致死性中毒病例。
A case of fatal poisoning by rifampicin.
作者信息
Plomp T A, Battista H J, Unterdorfer H, van Ditmarsch W C, Maes R A
出版信息
Arch Toxicol. 1981 Nov;48(4):245-52. doi: 10.1007/BF00319652.
The toxicologic findings of a fatal poisoning with rifampicin (Rimactan) are presented. The concentration of rifampicin and its two major metabolites 25-desacetylrifampicin and 3-formylrifamycin in post-mortem blood, urine, bile and liver at about 10 h after ingestion of 14-15 g was determined using a high-performance liquid chromatographic method. The results of the toxicological analyses were compared with findings in fatal and non-fatal intoxications and after therapeutic administration of the drug. Possible explanation for the fatal outcome is given.
本文报告了一例利福平（利美定）致死性中毒的毒理学发现。采用高效液相色谱法测定了摄入14 - 15克利福平约10小时后，尸检血液、尿液、胆汁和肝脏中利福平及其两种主要代谢产物25 - 去乙酰利福平和3 - 甲酰利福霉素的浓度。将毒理学分析结果与致命和非致命中毒以及药物治疗给药后的结果进行了比较。给出了导致致命后果的可能解释。
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