Siegers C P, Pentz R, Dageförde J
Arch Toxicol. 1981 Nov;48(4):293-7. doi: 10.1007/BF00319658.
Oral ingestion of about 80 ml of a 20% solution of paraquat (Gramoxone) by a 44 years-old male alcoholic was followed by an acute edema of the lungs and death within 24 hrs. The administration of corticosteroids as well as the employment of forced diuresis, charcoal hemoperfusion and hemodialysis did not prevent this acute lethal outcome. The very high initial plasma concentration of 2.56 mg/l dropped quickly after hemoperfusion and dialysis to 1.19 mg/l. In mice ingesting a 5% ethanol solution for one week the LD50 of paraquat was diminished to 80 (63 - 102) mg/kg p.o. as compared to 170 (126 - 229) mg/kg p.o. in controls indicating that alcohol is able to enhance the acute toxicity of paraquat.
一名44岁的男性酗酒者口服了约80毫升20%的百草枯（克无踪）溶液，随后肺部出现急性水肿，并在24小时内死亡。使用皮质类固醇以及强制利尿、活性炭血液灌注和血液透析均未能阻止这一致命的急性后果。最初血浆浓度非常高，达2.56毫克/升，血液灌注和透析后迅速降至1.19毫克/升。连续一周摄入5%乙醇溶液的小鼠，百草枯的经口半数致死量降至80（63 - 102）毫克/千克，而对照组为170（126 - 229）毫克/千克，这表明酒精能够增强百草枯的急性毒性。
