Vikhert A M, Bykovskaia K N
Arkh Patol. 1981;43(11):19-25.
Experimental autoimmune glomerulonephritis was reproduced in 10 generations of animals by parenteral inoculation on two occasions of 0.3 ml of a mixture (1 :1) of AF stimulator and 20% renal cortical layer homogenate. The animals were immunized with minimal doses which routinely did not cause renal pathology, however, in sequential regular immunization from generation to generation the renal pathology increased. The forth-fifth generation exhibited clinical signs typical of glomerulonephritis. Morphological examinations of the kidneys revealed mesangial-proliferative and membranous-proliferative glomerulonephritis.
通过两次经肠胃外接种0.3毫升AF刺激物与20%肾皮质层匀浆的混合物（1:1），在10代动物中诱发了实验性自身免疫性肾小球肾炎。用通常不会引起肾脏病变的最小剂量对动物进行免疫，然而，在一代又一代的连续定期免疫中，肾脏病变加重。第四至五代出现了肾小球肾炎的典型临床症状。对肾脏的形态学检查显示为系膜增生性和膜增生性肾小球肾炎。
