Givens C D, Johns M E, Cantrell R W
Arch Otolaryngol. 1981 Dec;107(12):730-4. doi: 10.1001/archotol.1981.00790480006002.
The treatment of 162 patients with squamous cell carcinoma of the tonsil seen at the University of Virginia Medical Center, Charlottesville, from 1955 through 1974 was reviewed. One hundred four patients form the basis of this report. The patients were grouped by the stage of disease, and then three- and five-year determinate survival, recurrences, distant metastases, and complications were examined. The treatment used was surgery, radiation, or a combination of preoperative radiation and surgery. The overall five-year determinate survival for stage I was 93.3%; stage II, 57%; stage III, 27%; and stage IV, 17%. The five-year determinate survivals of patients treated with surgery alone, radiation, and combination therapy were 88%, 27%, and 32%, respectively. The latter two treatment modalities were biased by a greater proportion of patients with stage III and IV disease, whereas surgery alone included a high proportion of patients with stage I and II disease. Based on this review and those reported in the literature, we recommend radical radiation therapy for stage I and II disease and combination radiation therapy and composite resection for stages III and IV.
对1955年至1974年在夏洛茨维尔弗吉尼亚大学医学中心就诊的162例扁桃体鳞状细胞癌患者的治疗情况进行了回顾。本报告基于其中104例患者。患者按疾病分期分组，然后对3年和5年的确定生存率、复发情况、远处转移和并发症进行了检查。所采用的治疗方法为手术、放疗或术前放疗与手术相结合。I期患者的总体5年确定生存率为93.3%；II期为57%；III期为27%；IV期为17%。单纯手术、放疗及联合治疗患者的5年确定生存率分别为88%、27%和32%。后两种治疗方式中III期和IV期疾病患者的比例更高，而单纯手术组中I期和II期疾病患者的比例较高。基于本回顾及文献报道，我们推荐I期和II期疾病采用根治性放疗，III期和IV期采用放疗联合复合切除术。
