正常成年人及遗传性高铁血红蛋白血症患者的高铁血红蛋白状态。
State of methaemoglobin in normal adults and in patients with hereditary methaemoglobinaemia.
作者信息
Perutz M F
出版信息
Biochem J. 1981 May 1;195(2):519-20. doi: 10.1042/bj1950519.
Abstract
The predominance of valency hybrids over fully oxidized methaemoglobin in the haemolysate from a methaemoglobinaemia patient can be explained by random oxidation of the haems, followed by re-assortment and co-migration of equally charged alpha beta-dimers in the electric field of the isoelectric-focusing gel.
摘要
高铁血红蛋白血症患者溶血产物中，价态杂化物相对于完全氧化的高铁血红蛋白占优势的现象，可以通过血红素的随机氧化，随后在等电聚焦凝胶电场中电荷相同的αβ-二聚体重新排列和共同迁移来解释。
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本文引用的文献
1
ON THE DISSOCIATION OF NORMAL ADULT HUMAN HEMOGLOBIN.关于正常成人血红蛋白的解离
Proc Natl Acad Sci U S A. 1963 Oct;50(4):774-82. doi: 10.1073/pnas.50.4.774.
2
Nonequivalence of chains in hemoglobin oxidation.血红蛋白氧化过程中链的不等效性。
Biochemistry. 1973 Nov 20;12(24):4946-9. doi: 10.1021/bi00748a020.
3
Analyis of met-form haemoglobins in human erythrocytes of normal adults and of a patient with hereditary methaemoglobinaemia due to deficiency of NADH-cytochrome b5 reductase.正常成年人及一名因烟酰胺腺嘌呤二核苷酸（NADH）-细胞色素b5还原酶缺乏导致遗传性高铁血红蛋白血症患者的人红细胞中高铁血红蛋白的分析。
Biochem J. 1979 Aug 1;181(2):505-7. doi: 10.1042/bj1810505.
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