血清脂蛋白对大鼠肝细胞膜腺苷酸环化酶活性的影响。
Effect of serum lipoproteins on the adenylate cyclase activity of rat liver plasma membranes.
作者信息
Ghiselli G, Sirtori C R, Nicosia S
出版信息
Biochem J. 1981 Jun 15;196(3):899-902. doi: 10.1042/bj1960899.
Abstract
Four rat lipoprotein classes [lymph chylomicrons, VLD (very-low-density), LD (low-density) and HD (high-density) lipoproteins] were tested for their ability to affect basal adenylate cyclase (EC 4.6.1.1) activity of rat liver plasma membranes. All the lipoproteins, with the exception of lymph chylomicrons, effectively increase the enzyme activity. VLD lipoproteins are the most active class (67% maximal increase), followed by HD lipoproteins (33%) and LD lipoproteins (23%). The effect of VLD lipoproteins is additive to that elicited by GTP or GTP plus glucagon (at least within a certain concentration range). VLD lipoproteins affect only the Vmax. of the enzyme, not the Km.
摘要
对四种大鼠脂蛋白类别[淋巴乳糜微粒、极低密度脂蛋白（VLD）、低密度脂蛋白（LD）和高密度脂蛋白（HD）]影响大鼠肝细胞膜基础腺苷酸环化酶（EC 4.6.1.1）活性的能力进行了测试。除淋巴乳糜微粒外，所有脂蛋白均能有效提高该酶的活性。极低密度脂蛋白是活性最高的类别（最大增加67%），其次是高密度脂蛋白（33%）和低密度脂蛋白（23%）。极低密度脂蛋白的作用与GTP或GTP加胰高血糖素所引发的作用是相加的（至少在一定浓度范围内）。极低密度脂蛋白仅影响该酶的最大反应速度（Vmax），而不影响米氏常数（Km）。
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