Kruglikov R I, Gol'dberg M V, Zabludovskii A L
Biol Bull Acad Sci USSR. 1980 Sep-Oct;7(5):432-4.
When 25 microgram of metenkephalin is injected subcutaneously into rats, the development of temporal associations is somewhat impaired, but the fixation of them is enhanced. The latter effect is observed more clearly when metenkephalin is injected not before, but immediately after the development of conditioned reflexes. Under the influence of metenkephalin, there is an increase in the incorporation of C14-leucine into the insoluble proteins of the hippocampus and basal ganglia. It is hypothesized that metenkephalin mainly affects the process of consolidation.
当将25微克甲硫氨酸脑啡肽皮下注射到大鼠体内时，时间联想的形成会受到一定程度的损害，但它们的巩固却得到增强。当甲硫氨酸脑啡肽不是在条件反射形成之前，而是在条件反射形成后立即注射时，后一种效应会更明显地观察到。在甲硫氨酸脑啡肽的影响下，海马体和基底神经节的不溶性蛋白质中C14-亮氨酸的掺入增加。据推测，甲硫氨酸脑啡肽主要影响巩固过程。
