Chernushenko E F, Chumak A A
Biull Eksp Biol Med. 1981 Nov;92(11):583-5.
Effect of preinjection of splenin to tuberculosis-infected guinea-pigs on the development of tuberculin shock and Bordet's phenomenon was examined. In animals exposed to tuberculin shock, splenin was found to increase blast transformation of lymphocytes in response to tuberculin, as well as the degree of the proliferative reactions in lymphoid organs. It was also demonstrated that administration of splenin led to the reduction of the complement titer and the foci of tuberculosis in the organs. In guinea-pigs with the induced Bordet's phenomenon, splenin exerted no beneficial immunomodulating effect, promoting the development of more severe tuberculous lesions in the internal organs.
研究了预先给感染结核的豚鼠注射脾素对结核菌素休克和博代现象发展的影响。在遭受结核菌素休克的动物中，发现脾素可增加淋巴细胞对结核菌素的增殖转化以及淋巴器官中的增殖反应程度。还证明，注射脾素会导致补体滴度降低以及器官中结核病灶减少。在诱发了博代现象的豚鼠中，脾素没有发挥有益的免疫调节作用，反而促使内脏中出现更严重的结核病变。
