[Effect of splenin on the development of tuberculin shock and Bordet's phenomenon in guinea pigs].

Effect of preinjection of splenin to tuberculosis-infected guinea-pigs on the development of tuberculin shock and Bordet's phenomenon was examined. In animals exposed to tuberculin shock, splenin was found to increase blast transformation of lymphocytes in response to tuberculin, as well as the degree of the proliferative reactions in lymphoid organs. It was also demonstrated that administration of splenin led to the reduction of the complement titer and the foci of tuberculosis in the organs. In guinea-pigs with the induced Bordet's phenomenon, splenin exerted no beneficial immunomodulating effect, promoting the development of more severe tuberculous lesions in the internal organs.