Karp G, Antman K, Canellos G
Cancer Clin Trials. 1981 Winter;4(4):465-7.
Forty-six patients with various malignancies refractory to standard chemotherapy were treated with VP-16-213 using a weekly schedule. Only one patient responded to this regimen. perivenous infiltration of VP-16-213 resulted in a soft-tissue ulceration; this side effect has not been reported before. We conclude that VP-16-213 is of little utility when used in a weekly fashion in previously treated patients.
46例对标准化疗难治的各种恶性肿瘤患者采用每周一次的方案接受VP-16-213治疗。只有1例患者对该方案有反应。VP-16-213的静脉周围浸润导致软组织溃疡；这种副作用以前未见报道。我们得出结论，对于先前接受过治疗的患者，以每周一次的方式使用VP-16-213几乎没有效果。
