Pedersen U, Balle V H, Greisen O
Clin Otolaryngol Allied Sci. 1981 Oct;6(5):329-33. doi: 10.1111/j.1365-2273.1981.tb01807.x.
In a 12-month period, brush biopsy through a fibreoptic bronchoscope was performed on 125 consecutive patients who were clinically or radiographically suspected of lung cancer. Of the patients, 62 appeared to have lung cancer. Cytological analysis of the brush-biopsy specimens was positive in 69%. A total of 58% had positive biopsy, and 58% had cancer cells in the bronchial secretion aspirated during the bronchoscopy. Thirty-five per cent had positive mediastinoscopy. When the methods of examination were combined, the diagnosis could be established in 90% of the patients. The study shows that brush biopsy and cytological analysis, in combination with the other methods of examination, increase the diagnostic sensitivity in bronchoscopically visible tumours. In bronchoscopically invisible tumours, brush cytological analysis, together with the study of bronchial secretion and fine-needle puncture, is the most effective diagnostic method. The diagnostic possibilities can presumably be further improved by the use of fluoroscopic control in two places during the bronchoscopy.
在12个月期间，对125例临床或影像学怀疑患有肺癌的连续患者进行了纤维支气管镜刷检活检。其中，62例患者似乎患有肺癌。刷检活检标本的细胞学分析阳性率为69%。活检阳性率为58%，支气管镜检查时吸出的支气管分泌物中癌细胞阳性率为58%。纵隔镜检查阳性率为35%。当联合使用多种检查方法时，90%的患者能够确诊。该研究表明，刷检活检和细胞学分析与其他检查方法相结合，可提高支气管镜可见肿瘤的诊断敏感性。对于支气管镜不可见的肿瘤，刷检细胞学分析与支气管分泌物研究及细针穿刺相结合是最有效的诊断方法。通过在支气管镜检查期间在两个部位使用荧光透视控制，诊断可能性可能会进一步提高。
