茶碱在早产新生儿中的分布。

Theophylline distribution in the premature neonate.

作者信息

Bonati M, Latini R, Marra G, Assael B M, Parini R

出版信息

Dev Pharmacol Ther. 1981;3(2):65-73. doi: 10.1159/000457424.

Abstract

Theophylline (T) tissue distribution was studied in 11 premature newborns treated with T for prematurity apnea, who had died from severe pathology. To investigate the pattern of distribution of T, in particular the role of the blood-brain barrier in this period of life, two animal species were employed (rat and guinea pig), differing widely in their postnatal development. T was administered to the animals acutely and chronically and the resulting data were compared to human findings. In human prematures no specific accumulation and a wide variety in tissue concentrations, as in tissue/blood ratios, were observed. In the rat, unlike the guinea pig, brain/blood ratios of T concentration declined as postnatal age rose, suggesting that development of the blood-brain barrier plays a major role.

摘要

对11例因早产呼吸暂停接受茶碱（T）治疗但死于严重病变的早产新生儿进行了茶碱（T）组织分布研究。为了研究T的分布模式，特别是血脑屏障在这一生命阶段的作用，使用了两种出生后发育差异很大的动物物种（大鼠和豚鼠）。对动物进行急性和慢性T给药，并将所得数据与人类研究结果进行比较。在人类早产儿中，未观察到T的特异性蓄积，且组织浓度（如组织/血液比率）存在很大差异。与豚鼠不同，在大鼠中，T浓度的脑/血比率随着出生后年龄的增加而下降，这表明血脑屏障的发育起主要作用。