Kwan C Y, Daniel E E
Eur J Pharmacol. 1981 Nov 5;75(4):321-4. doi: 10.1016/0014-2999(81)90561-6.
Alkaline phosphatase activity and Ca2+ accumulation were examined in the isolated plasma membrane fractions from small arteries and veins of spontaneously hypertensive (SHR) and normotensive (WKY). Increased Ca2+ binding by plasma membrane fractions from veins, decreased ATP-dependent Ca2+ accumulation by those from arteries and increased alkaline phosphatase activity in both fractions from SHR were observed. We conclude that biochemical abnormalities in vascular smooth muscle cell membrane cannot be explained solely as adaptive changes induced by elevated blood pressure.
在自发性高血压大鼠（SHR）和正常血压大鼠（WKY）的小动脉和静脉分离的质膜组分中检测了碱性磷酸酶活性和Ca2+积累。观察到来自静脉的质膜组分中Ca2+结合增加，来自动脉的质膜组分中ATP依赖性Ca2+积累减少，并且SHR的两个组分中的碱性磷酸酶活性均增加。我们得出结论，血管平滑肌细胞膜中的生化异常不能仅解释为血压升高引起的适应性变化。
