• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

建立白蛋白缺乏和黄疸大鼠品系。

Establishment of an albumin-deficient and jaundiced strain of rats.

作者信息

Shumiya S, Nagase S

出版信息

Jikken Dobutsu. 1981 Jul;30(3):291-7. doi: 10.1538/expanim1978.30.3_291.

DOI:10.1538/expanim1978.30.3_291
PMID:7318933
Abstract

An albumin deficient and jaundiced rat (AJR) strain was established from crosses between Albumin-Deficient rats (NAR) and jaundiced Gunn rats. AJRs have a double homozygous mutant trait (alb/alb, j/j), and systemic jaundice and various neurological signs are observed 5--7 days after birth, kernicterus occurs and they die within three weeks after birth. This strain of rats may serve as a model of human kernicterus and also be useful in elucidating the mechanism of bilirubin metabolism.

摘要

白蛋白缺乏且黄疸的大鼠(AJR)品系是由白蛋白缺乏大鼠(NAR)和黄疸Gunn大鼠杂交培育而成。AJR具有双纯合突变性状(alb/alb,j/j),出生后5 - 7天出现全身性黄疸和各种神经症状,发生核黄疸,出生后三周内死亡。这种大鼠品系可作为人类核黄疸的模型,也有助于阐明胆红素代谢机制。

相似文献

1
Establishment of an albumin-deficient and jaundiced strain of rats.建立白蛋白缺乏和黄疸大鼠品系。
Jikken Dobutsu. 1981 Jul;30(3):291-7. doi: 10.1538/expanim1978.30.3_291.
2
Treatment and improvement of the breeding system of the albumin-deficient and jaundiced strain of rats.
Jikken Dobutsu. 1983 Apr;32(2):97-102. doi: 10.1538/expanim1978.32.2_97.
3
Transfer of the heritable nonhemolytic jaundice trait from the Gunn rat to the Sprague-Dawley rat.
Lab Anim Sci. 1987 Apr;37(2):172-5.
4
A difference in mortality between two strains of jaundiced rats.两种黄疸大鼠品系之间的死亡率差异。
Pediatrics. 1991 Jan;87(1):88-93.
5
Penetration of bilirubin into the brain in albumin-deficient and jaundiced rats (AJR) and Nagase analbuminemic rats (NAR).
J Biochem. 1984 Dec;96(6):1705-12. doi: 10.1093/oxfordjournals.jbchem.a135003.
6
Establishment of an albumin-deficient and fatty strain of rats.
Jikken Dobutsu. 1984 Jan;33(1):97-103. doi: 10.1538/expanim1978.33.1_97.
7
Albumin-deficient rat mutant: an animal model for analbuminemia.白蛋白缺乏大鼠突变体:一种无白蛋白血症的动物模型。
Jikken Dobutsu. 1980 Jan;29(1):33-8. doi: 10.1538/expanim1978.29.1_33.
8
Auditory brainstem response and unbound bilirubin in jaundiced (jj) Gunn rat pups.黄疸(jj)Gunn 大鼠幼崽的听觉脑干反应与游离胆红素
Biol Neonate. 2001 Aug;80(2):158-62. doi: 10.1159/000047136.
9
Identification and clinical examination of jaundiced rats.
Z Versuchstierkd. 1989;32(1):1-5.
10
The congenic normal R/APfd and jaundiced R/APfd-j/j rat strains: a new animal model of hereditary non-haemolytic unconjugated hyperbilirubinaemia due to defective bilirubin conjugation.同基因正常R/APfd和黄疸型R/APfd-j/j大鼠品系:一种因胆红素结合缺陷导致的遗传性非溶血性未结合型高胆红素血症的新动物模型。
Lab Anim. 1986 Oct;20(4):335-42. doi: 10.1258/002367786780808758.

引用本文的文献

1
Ideal Experimental Rat Models for Liver Diseases.肝脏疾病的理想实验大鼠模型
Korean J Hepatobiliary Pancreat Surg. 2011 May;15(2):67-77. doi: 10.14701/kjhbps.2011.15.2.67. Epub 2011 May 31.
2
Plasma clearance of sulfobromophthalein and its interaction with hepatic binding proteins in normal and analbuminemic rats: is plasma albumin essential for vectorial transport of organic anions in the liver?正常大鼠和无白蛋白血症大鼠中磺溴酞的血浆清除率及其与肝脏结合蛋白的相互作用:血浆白蛋白对肝脏中有机阴离子的向性转运是否必不可少?
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7654-8. doi: 10.1073/pnas.80.24.7654.