Itoh O, Torikai T, Satoh M, Okumura O, Osawa T
Gan. 1981 Jun;72(3):370-6.
Human ceruloplasmin was found to have a neutralizing effect against the toxohormone activities of the basic protein isolated from Ehrlich carcinoma cells; this basic protein decreases the levels of serum iron and liver catalase activity upon intraperitoneal injection into mice and shows direct cytotoxicity toward normal mouse lymphocytes and macrophages. Furthermore, it was also shown that ceruloplasmin has antitumor activity against sarcoma-180 cells implanted in ICR mice.
人们发现，人铜蓝蛋白对从艾氏癌细胞中分离出的碱性蛋白的毒素激素活性具有中和作用；这种碱性蛋白在腹腔注射到小鼠体内后会降低血清铁水平和肝脏过氧化氢酶活性，并对正常小鼠淋巴细胞和巨噬细胞表现出直接细胞毒性。此外，还表明铜蓝蛋白对植入ICR小鼠体内的肉瘤-180细胞具有抗肿瘤活性。
