Pereira B M, Balasubramanian K, Govindarajulu P
Int J Androl. 1981 Oct;4(5):582-9. doi: 10.1111/j.1365-2605.1981.tb00740.x.
The effect of castration and treatment with testosterone propionate, androstenedione and oestradiol-17 beta on the coagulating gland LDH activity and its isozymes were studied. Castration reduced the total LDH activity and administration of testosterone propionate alone was able to restore it back to sham operated control levels. Regarding LDH isozymes, the LDH3 and LDH4 responded very similarly to testosterone and oestradiol. LDH5 was significantly increased only in the androgen treated groups. The post-castration decrease in total M-subunits was restored to sham operated control levels in the testosterone propionate treated group. This was mainly contributed by the LDH3, LDH4 and LDH5 isozymes. The changes observed due to testosterone propionate and androstenedione treatments have been attributed to the rejuvenation of tissue from the castration induced losses. The oestradiol induced events have been associated with the growth of fibro muscular layers observed under similar experimental conditions.
研究了去势以及用丙酸睾酮、雄烯二酮和17β-雌二醇治疗对凝固腺乳酸脱氢酶（LDH）活性及其同工酶的影响。去势降低了总LDH活性，单独给予丙酸睾酮能够使其恢复到假手术对照组水平。关于LDH同工酶，LDH3和LDH4对睾酮和雌二醇的反应非常相似。仅在雄激素治疗组中，LDH5显著增加。在丙酸睾酮治疗组中，去势后总M亚基的降低恢复到假手术对照组水平。这主要由LDH3、LDH4和LDH5同工酶所致。观察到的丙酸睾酮和雄烯二酮治疗引起的变化归因于组织从去势诱导的损失中恢复活力。在相似实验条件下观察到，雌二醇诱导的事件与纤维肌层的生长有关。
