Nagaraja T G, Avery T B, Bartley E E, Galitzer S J, Dayton A D
J Anim Sci. 1981 Jul;53(1):206-16. doi: 10.2527/jas1981.531206x.
Intraruminal administration of lasalocid or monensin (1.3 mg/kg body weight) effectively prevented in glucose- or corn-induced lactic acidosis in cattle. Administering the antibiotics for 7 days before experimentally inducing acidosis with corn (27.5 g/kg body weight), effectively prevented acidosis, while 2 days' were sufficient to prevent glucose-induced acidosis (12.5 g/kg body weight). The different responses observed in the two trials probably stemmed from the difference in amounts of carbohydrate used to induce acidosis. Antibiotic-treated cattle had higher rumen pH values and lower L(+) and D(-) lactate concentrations that control cattle that received no antibiotics. Ruminal VFA in control cattle decreased, while total VFA and the molar proportion of propionate increased in antibiotic-treated cattle after grain engorgement. Control cattle exhibited classic signs of acidosis, such as lowered blood pH; increased blood lactate, particularly D(-) isomer; hemoconcentration, and depleted alkali reserve with a pronounced based deficit. Antibiotic-treated cattle exhibited no signs of systemic acidosis.
瘤胃内给予拉沙洛西或莫能菌素（1.3毫克/千克体重）可有效预防牛因葡萄糖或玉米诱发的乳酸酸中毒。在用玉米（27.5克/千克体重）实验性诱发酸中毒前7天给予抗生素，可有效预防酸中毒，而2天的给药时间就足以预防葡萄糖诱发的酸中毒（12.5克/千克体重）。两项试验中观察到的不同反应可能源于用于诱发酸中毒的碳水化合物量的差异。用抗生素处理的牛的瘤胃pH值较高，L(+)和D(-)乳酸浓度低于未接受抗生素的对照牛。对照牛的瘤胃挥发性脂肪酸减少，而用抗生素处理的牛在谷物采食后总挥发性脂肪酸和丙酸的摩尔比例增加。对照牛表现出酸中毒的典型症状，如血液pH值降低；血液乳酸增加，尤其是D(-)异构体；血液浓缩，碱储备耗尽并有明显的碱缺乏。用抗生素处理的牛没有表现出全身酸中毒的迹象。
