Ueda M, Matsuda S, Tonda K, Matsunaga K
Jpn J Pharmacol. 1978 Aug;28(4):617-26. doi: 10.1254/jjp.28.617.
Antihypertensive and diuretic effects of trichlormethiazide (TCM) were investigated in the spontaneously hypertensive rats (SHR). The antihypertensive effect of TCM in an acute experiment was observed in male SHR only at a dose over 10 mg/kg given intraperitoneally and not in female SHR and normotensive Kyoto Wistar rats. In a subacute experiment (6 weeks), TCM retarded the development of hypertension in the male SHR loaded with 1% saline solution at an oral dose over 1 mg kg-1 day-1 and such had a diuretic effect. Oral administration of TCM and hydrochlorothiazide (HCT) at 10 mg kg-1 day-1 retarded the development of hypertension in the saline loaded female SHR to the same degree, but the relationship between antihypertensive and diuretic effects of both compounds was obscure. Except for decreases of water contents in the thoracic artery and wet weights of hearts, the electrolyte, uric acid, catecholamine and 5-hydroxytryptamine contents in the serum or/and organs were not affected by either TCM or HCT. It is concluded that the antihypertensive effect of TCM and HCT can be observed in SHR with a saline-load, and that the effect may be due to diuretic actions in the male. The relationship was not apparent in female SHR.
研究了三氯噻嗪（TCM）对自发性高血压大鼠（SHR）的降压和利尿作用。在急性实验中，仅当腹腔注射剂量超过10mg/kg时，TCM对雄性SHR有降压作用，而对雌性SHR和正常血压的京都Wistar大鼠无此作用。在亚急性实验（6周）中，当口服剂量超过1mg kg-1天-1时，TCM延缓了饮用1%盐溶液的雄性SHR高血压的发展，且具有利尿作用。以10mg kg-1天-1的剂量口服TCM和氢氯噻嗪（HCT）对饮用盐水的雌性SHR高血压发展的延缓程度相同，但两种化合物的降压和利尿作用之间的关系尚不清楚。除胸主动脉含水量和心脏湿重降低外，血清或/和器官中的电解质、尿酸、儿茶酚胺和5-羟色胺含量均未受TCM或HCT的影响。得出结论：在饮用盐水的SHR中可观察到TCM和HCT的降压作用，且该作用可能归因于雄性大鼠的利尿作用。在雌性SHR中，这种关系不明显。
