Kamata K, Aoki H, Kameyama T
J Pharmacobiodyn. 1981 Oct;4(10):788-93. doi: 10.1248/bpb1978.4.788.
The electrical stimulation of the caudate nucleus could induce a caudate spindle in the rat as in case of the cat and monkey. The spindle was enhanced by atropine (3-10 mg/kg, i.v.) or morphine (3-10 mg/kg, i.v.) and the effect of these drugs were completely abolished by eserine (0.3 mg/kg, i.v.), but not by methysergide (1 mg/kg, i.v.), PCPA (400 mg/kg, i.p. for 3 days) or reserpine (3 mg/kg, i.p. for 2 days). An intraventricular injection of atropine (5-10 microgram/rat) or morphine (10 microgram/rat) exerted a facilitatory action on the spindle, while an intrathalamic and intracaudate injection of atropine (5-50 microgram/rat) showed a suppressive action. The spindle was also markedly enhanced by the microinjection of atropine (15-30 microgram/rat) or morphine (30 microgram/rat) into the reticular formation, and these actions were completely antagonized by eserine (0.3 mg/kg i.v.), but only partially by methysergide (4 microgram/rat, intraventricular administration.) These results suggest that the cholinergic system may play an important role in the regulation of the caudate spindle.
对大鼠尾状核进行电刺激可诱发尾状核纺锤波，就像猫和猴的情况一样。阿托品（3 - 10毫克/千克，静脉注射）或吗啡（3 - 10毫克/千克，静脉注射）可增强纺锤波，而这些药物的作用可被毒扁豆碱（0.3毫克/千克，静脉注射）完全消除，但不能被甲基麦角新碱（1毫克/千克，静脉注射）、对氯苯丙氨酸（400毫克/千克，腹腔注射，连续3天）或利血平（3毫克/千克，腹腔注射，连续2天）消除。脑室内注射阿托品（5 - 10微克/只大鼠）或吗啡（10微克/只大鼠）对纺锤波有促进作用，而丘脑内和尾状核内注射阿托品（5 - 50微克/只大鼠）则表现出抑制作用。向网状结构微量注射阿托品（15 - 30微克/只大鼠）或吗啡（30微克/只大鼠）也可显著增强纺锤波，这些作用可被毒扁豆碱（0.3毫克/千克，静脉注射）完全拮抗，但仅被甲基麦角新碱（4微克/只大鼠，脑室内给药）部分拮抗。这些结果表明，胆碱能系统可能在尾状核纺锤波的调节中起重要作用。
