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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Montastruc J L, Gaillard-Plaza G, Thomas J, Montastruc P

J Pharmacol. 1981 Nov-Dec;12(4):465-70.

The effect of bilateral nephrectomy (24 hours before) on the antihypertensive action of dl-propranolol (1 mg/kg iv) was studied in acute neurogenic hypertensive dogs. 2. Bilateral nephrectomy induced an increase in plasma urea and creatinine, a decrease in protein values but did not change the other plasma values (table I). 3. Propranolol always induced a decrease in blood pressure (fig. 1) and heart rate (fig. 2) in bilateral nephrectomized dogs. 4. These results suggest that renal mechanisms (especially modifications of renin release) did not play a predominant or exclusive role in the antihypertensive action of beta-blocking agents under our experimental conditions.

在急性神经源性高血压犬中研究了双侧肾切除（术前24小时）对dl-普萘洛尔（1毫克/千克静脉注射）降压作用的影响。2. 双侧肾切除导致血浆尿素和肌酐升高、蛋白质值降低，但未改变其他血浆值（表I）。3. 普萘洛尔在双侧肾切除的犬中总是导致血压降低（图1）和心率降低（图2）。4. 这些结果表明，在我们的实验条件下，肾脏机制（尤其是肾素释放的改变）在β受体阻滞剂的降压作用中并未起主要或唯一作用。

Montastruc J L, Gaillard-Plaza G, Thomas J, Montastruc P

J Pharmacol. 1981 Nov-Dec;12(4):465-70.

The effect of bilateral nephrectomy (24 hours before) on the antihypertensive action of dl-propranolol (1 mg/kg iv) was studied in acute neurogenic hypertensive dogs. 2. Bilateral nephrectomy induced an increase in plasma urea and creatinine, a decrease in protein values but did not change the other plasma values (table I). 3. Propranolol always induced a decrease in blood pressure (fig. 1) and heart rate (fig. 2) in bilateral nephrectomized dogs. 4. These results suggest that renal mechanisms (especially modifications of renin release) did not play a predominant or exclusive role in the antihypertensive action of beta-blocking agents under our experimental conditions.

在急性神经源性高血压犬中研究了双侧肾切除（术前24小时）对dl-普萘洛尔（1毫克/千克静脉注射）降压作用的影响。2. 双侧肾切除导致血浆尿素和肌酐升高、蛋白质值降低，但未改变其他血浆值（表I）。3. 普萘洛尔在双侧肾切除的犬中总是导致血压降低（图1）和心率降低（图2）。4. 这些结果表明，在我们的实验条件下，肾脏机制（尤其是肾素释放的改变）在β受体阻滞剂的降压作用中并未起主要或唯一作用。